Southampton and Manchester United have named their starting XIs or Saturday’s early kick off at St Mary’s.
The big news for United is that new signing Manuel Ugarte is on the bench having returned late from international duty with Christian Eriksen taking his place in midfield.
Casemiro is also on the bench following his high-profile mistakes in the defeat to Liverpool.
With Rasmus Hojlund still unavailable, Amad Diallo and Joshua Zirkzee leads the attack alongside Marcus Rashford.
Manchester United: Onana; Mazraoui, De Ligt, Martinez, Dalot; Eriksen, Mainoo, Bruno Fernandes; Zirkzee, Amad, Rashford
For Saints meanwhile, striker Ben Brereton Diaz starts despite having been withdrawn after only 34 minutes in Chile’s defeat to Bolivia in midweek.
Teenager Tyler Dibling also takes his place in the midfield.